Vision
To be a Model Center for Drug Discovery and Development Research throughout the Middle East and Africa
Mission
Providing the required facilities and infrastructure required for performing a complete sophisticated research for drug discovery and development as well as the preparation of new generation of well-trained researchers in this field and providing different training and continuous education programs for students and young researchers.
1. Discovery and development of new entities from the different available natural resources including plants, Marine organisms and microorganisms.
2. Synthesis of new bioactive drug molecules applying sophisticated computer aided drug design techniques.
3. Performing different research Studies (anticancer, anti inflammatory) with other centers
4. Providing continuous education facility through different workshops in the field of drug discovery and analysis for researchers in home or abroad.
5. Providing a fee-for-service services for the research communities including running different ex* pefimental procedures related to drug discovery and development field through the available facilities in the center.
6. Providing scientific consultations for the related bodies including ministry of health and population, drug companies and different research institutes working in drug discovery and development.
7. Exchange of experience through performing cooperation agreements with similar research bodies inside ana abroad.
8. Providing training opportunities for undergraduate students..
- Tissue Culture Lab. (not completed)
- LCMS Lab.
- NMRLab.
- Extraction and chromatography lab. Seminar and training hall.
- Secretary
SN |
Title |
Year |
Authors |
1. |
Gastroprotective effects of Erythrina speciosa (Fabaceae) leaves cultivated in Egypt against ethanol-induced gastric ulcer in rats |
2020 |
Nouran M. Fahmy, Eman Al-Sayed, Haidy E. Michel, Mohamed El-Shazly, Abdel Nasser B, Singab |
2. |
Caspicaiene: a new kaurene diterpene with anti- tubercular activity from an Aspergillus endophytic isolate in Gleditsia caspia desf |
2020 |
Ashaimaa Y Moussa, Hagar A Sobhy, Omayma A Eldahshan, Abdel Nasser B Singab |
3. |
Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model |
2020 |
Mariam I Gamal El-Din, Fadia S Youssef, Riham S Said, Mohamed L Ashour, Omayma A Eldahshan, Abdel Nasser B Singab |
4. |
A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities |
2020 |
Mohamed MM AbdelRazek, Ashaimaa Yehia Moussa, Mohamed A El-Shanawany. Abdel Nasser B Singab |
5. |
Two clerodane diterpenes isolated from Polyalthia longifolia leaves: comparative structural features, anti-histaminic and anti-Helicobacter pylori activities |
2020 |
Martina P Edmond, Nada M Mostafa, Mohamed El-Shazly, Abdel Nasser B Singab |
6. |
New y-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats |
2020 |
Mariam I Gamal El-Din, Fadia S Youssef, Mohamed L Ashour, Omayma A Eldahshan, Abdel Nasser B Singab |
7. |
Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors |
2020 |
Sayed K Ramadan, Eman Z Elrazaz, Khaled AM Abouzid, Abeer M El-Naggar |
8. |
Isolation and Structure Elucidation of Compounds from Coccinia grandis Leaves Extract |
2019 |
Somaia A. Al-Madhagy, Nada M. Mostafa 1, Fadia S. Youssef, Ghada E. A. Awad. Omayma A. Eldahshan, Abdel Nasser B. Singab |
9. |
New secondary metabolites from the mangrove- derived fungus Aspergillus sp. AV-2 |
2019 |
Ahmed M. Elissawy, Sherif S. Ebadaa,, Mohamed L. Ashour, Mona El-Neketi, Weaam Ebrahimd, AbdelNasser B. Singab |
10. |
Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound |
2019 |
Nouran M. Fahmy, Eman Al-Sayed, Saad Moghannem,Faizul Azam, Mohamed El-Shazly, and Abdel Nasser Singab |
11. |
Pulchranin A: First report of isolation from an endophytic fungus and its inhibitory activity on cyclin dependent kinases |
2019 |
Ashaimaa Y. Moussa, Nada M. Mostafa & Abdel Nasser B. Singab |
12. |
Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation |
2019 |
Menna-Allah W Shalaby, Eman ME Dokla. Rabah AT Serya, Khaled AM Abouzid |
13. |
Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities |
2019 |
Maiy Y Jaballah, Rabah AT Serya, Nasser Saad. Sohair M Khojah, Marawan Ahmed, Khaled Barakat, Khaled AM Abouzid |
14. |
Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity |
2019 |
Nevine MY Elsayed, Rabah AT Serya, Mai F Tolba, Marawan Ahmed, Khaled Barakat, Dalal A Abou El Ella, Khaled AM Abouzid |
15. |
Identification of new pyrrole [2, 3-d] pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling |
2018 |
Mai Adel, Rabah AT Serya, Deena S Lasheen, Khaled AM Abouzid |
16. |
Surmounting the resistance against EGFR inhibitors through the development of thieno [2, 3-d] pyrimidine-based dual EGFR/HER2 inhibitors |
2018 |
Sandra N Milik, Amal Kamal Abdel-Aziz, Deena S Lasheen, Rabah AT Serya, Saverio Minucci, Khaled AM Abouzid |
17. |
Design, synthesis, molecular docking study, and biological evaluation of salicylaldimine derivatives as potential histone deacetylases inhibitors (FIDACi) and anticancer agents |
2018 |
Heba M Hesham, Deena S Lasheen, Khaled AM Abouzid |
18. |
Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity |
2018 |
Monia Hossam. Deena S Lasheen, Nasser SM Ismail, Ahmed Esmat, Ahmed M Mansour, Abdel Nasser B Singab, Khaled AM Abouzid |
19.. |
Study of the anti-allergic and antiinflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models |
2018 |
Amany A Thabet, Fadia S Youssef, Michal Korinek, Fang-Rong Chang, Yang-Chang Wu, Bing-Hung Chen, Mohamed El-Shazly. Abdel Nasser B Singab, Tsong-Long Hwang |
20. |
Spiroarthrinols a and B, two novel meroterpenoids isolated from the spongederived fungus Arthrinium sp |
2017 |
Ahmed M Elissawy, Sherif S Ebada, Mohamed L Ashour, Ferhat C Ozkaya, Weaam Ebrahim, AbelNasser B Singab. Peter Proksch |
21. |
Phytochemical Investigation, Antitumor Activity, and Hepatoprotective Effects of Acrocarpus fraxinifolius Leaf Extract |
2017 |
Heba AS ElNashar, Omayma A Eldahshan, Omania E Elshawi, Abdel Nasser B Singab |
22. |
Anti-Inflammatory and Analgesic Activities of Tcrminalia Muelleri Benth. (Combretaceae) |
2017 |
Nouran M Fahmy, Eman AlSayed, Mohamed M AbdelDaim, Abdel Nasser Singab |
23. |
Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract |
2017 |
NM Mostafa, OA Eldahshan, HA El-Beshbishy. AN Singab |
24. |
Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics |
2017 |
Fadia S Youssef, Rola M Labib, Omayma A Eldahshan, Abdel Nasser B Singab |
25. |
Furo[2,3-d|pyrimidine based derivatives as kinase inhibitors and anticancer agents |
2016 |
Marwa A Aziz, Rabah AT Serya, Deena S Lasheen, Khaled AM Abouzid |
26. |
Cytotoxic Oleanane-Type Saponins from the Leaves of Albizia anthelmintica Brongn. |
2016 |
Eman AID Sayed. Omayma A Eldahshan, Dina M Bahgat, Abdel Nasser B Singab |
27. |
Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae) |
2016 |
Nada M Mostafa, Mohamed L Ashour, Omayma A Eldahshan, Abdel Nasser B Singab |
28. |
Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents |
2016 |
Marwa A Aziz, Rabah AT Serya, Deena S Lasheen, Amal Kamal Abdel-Aziz, Ahmed Esmat, Ahmed M Mansour, Abdel Nasser B Singab, Khaled AM Abouzid |
29. |
Synthesis and in vitro antiproliferative activity of novel pyrazolo [3, 4-d] pyrimidine derivatives |
2015 |
Nermin S Abdou, Rabah AT Serya, Ahmed Esmat, Mai F Tolba, Nasser SM Ismail, Khaled AM Abouzid |
30. |
Bioactive Terpenes from Marine-Derived Fungi |
2015 |
Ahmed M Elissawy, Mohamed El-Shazly, Sherif S Ebada, AbdelNasser B Singab, Peter Proksch |
SN |
Title of thesis |
Year |
Presented by |
Faculty/ Univ. |
Status Finished/ running |
1. |
Comparative chemical study for the bioactive metabolites isolated from marine organisms and their associated fungi |
2017 |
Ahmed Elissawy |
Pharmacy/Ain shams university |
Finished /PhD |
2. |
Phytochemical and biological studies for some plants belonging to family Araliacae |
2019 |
Naglaa Mostafa |
Pharmacy/Ain shams university |
Finished/PhD |
3. |
Phytochemical and biological study on certain plants belonging to family Malvaceae |
2020 |
Mariam Ibrahim |
Pharmacy/Ain shams university |
Finished/PhD |
4. |
Phytochemical and biological studies for some plants belonging to family Fabacae |
202 0 |
Nouran Fahmy |
Pharmacy/Ain shams university |
Finished/PhD |
5. |
Phytochemical and biological studies for some plants belonging to family Anacardiaceae |
202 0 |
Heba El- Nashar |
Pharmacy/Ain shams university |
Finished/PhD |
6. |
Chemical and biological studies to some plants belonging to family Malvaceae |
201 8 |
Amany thabet |
Pharmacy/Ain shams university |
Finished/MSc |
7. |
Phytochemical and biological studies on Araucaria bediolia family Araucariaceae cultivated in Egypt |
201 8 |
Aya Talaat |
Pharmacy/Ain shams university |
Finished/MSc |
8. |
Phytochemical and biological studies on Spondias mangifera (Linh) Family Anacardiacae |
202 0 |
Salma Sameh |
Pharmacy/Ain shams university |
Finished/MSc |
9. |
Phytochemical and Biological studies on Brownea grandiceps belonging to family Fabacae |
|
Doaa Korany |
Pharmacy/Ain shams university |
Running/PhD |
10. |
Phytochemical and Biological study on Bontia daphnoids and Leucophyllum frutescens (Family Scrophulariacae) |
|
Amany Thabet |
Pharmacy/Ain shams university |
Running/PhD |
11. |
Phytochemical and Biological studies on plants belonging to genus Cestrum Family Solanacae |
|
Dina Bahgat |
Pharmacy/Ain shams university |
Running/PhD |
12. |
Phytochemical and biological study on Polyalthia longifolia Family Annonacae |
|
Martina Philip |
Pharmacy/Ain shams university |
Running/MSc. |
13. |
Bioactive secondary metabolites of Gelditsia caspica Family Fabacae |
|
Hager Ashraf |
Pharmacy/Ain shams university |
Running/MSc |
14. |
Phytochemical and biological studies on Polyalthia suberosa( Family Annonaceae) cultivated in Egypt |
|
Orchid Mahmoud |
Pharmacy/Ain shams university |
Running/MSc |
15. |
Phytochemical and biological studies on certain plants belonging to genus Erythrina (Family Fabaceae) |
|
Ahmed Mohsen |
Pharmacy/Ain shams university |
Running/MSc |
16. |
Chemical Investigation of endosyrnbiotic fungi isolated from selected marine invertebrates collected from the Red sea Egypt |
|
Reem Helmy |
Pharmacy/Ain shams university |
Running/MSc |
17. |
Metabolic profiling of selected Iris species belonging to Family Iridaceae:Comparative study |
|
Suzan Mahmoud |
Pharmacy/Ain shams university |
Running/MSc |
18. |
Comparative study of the bioactive metabolites of Morus sp. roots cultivated in Egypt and the associated endophytic fungi |
|
Khadiga Amr |
Pharmacy/Ain shams university |
Running/MSc |
19. |
Isolation of bioactive natural products from endophytic fungi associated with Canna Indica family cannaceae |
|
Ashrqat Ismail |
Pharmacy/Ain shams university |
Running/MSc |
A.Ain shams University
1-Bioactive Secondary Metabolites from Plants and their Symbiotic Fungi
B.STDF
1. Drug Discovery of new Anti-infective and Anti-cancer agents
2. Bioactive Metabolites from Marine Endosymbiotic Fungi
Joint Egyptian- Japanese Project
1. Research teams performing different research work mainly focusing on discovery of drug entities either naturally isolated or completely synthetic as well as bioassay evaluation.
2. Applying for different projects from different funding agencies.
3. International cooperation.
Workshops for researchers and students
(undergraduate and postgraduate).
1. Performing different analytical experiments for researchers with cost (25% discount for postgraduate of Faculty of pharmacy - Ain Shams University.
2. Providing consultations for pharmaceutical companies Training and workshops.
E-mail: ddr_d2013@pharma.asu.edu.eg
Address: African Union ST./Abbassia/Cairo/Egypt/11566
Phone: +2 024012466